Here is the perfect solution for this:https://forum.zorin.com/t/take-area-screenshot-without-saving-in-disk-in-gnome-screenshot/43996/11?u=sh_fahim
basically add this command as your custom keyboard shortcut and you're good to go:bash -c 'gnome-screenshot -af "$XDG_RUNTIME_DIR"/_custom_screenshot && xclip "$XDG_RUNTIME_DIR"/_custom_screenshot -selection clipboard -target image/png; rm "$XDG_RUNTIME_DIR"/_custom_screenshot'